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Prospective multicentric randomized study comparing periareolar and peritumoral injection of radiotracer and blue dye for the detection of sentinel lymph node in breast sparing procedures: FRANSENODE trial.
Rodier, Jean-François; Velten, Michel; Wilt, Marc; Martel, Pierre; Ferron, Gwanaël; Vaini-Elies, Véronique; Mignotte, Hervé; Brémond, Alain; Classe, Jean-Marc; Dravet, François; Routiot, Thierry; de Lara, Christine Tunon; Avril, Antoine; Lorimier, Gérard; Fondrinier, Eric; Houvenaeghel, Gilles; Avigdor, Sandrine.
Afiliación
  • Rodier JF; French Comprehensive Cancer Centers of Strasbourg, Toulouse, Lyon, Nantes, Bordeaux, Marseille, France. jrodier@strasbourg.fnclcc.fr
J Clin Oncol ; 25(24): 3664-9, 2007 Aug 20.
Article en En | MEDLINE | ID: mdl-17485709
PURPOSE: To determine the optimal injection path for blue dye and radiocolloid for sentinel lymph node (SLN) biopsy in early breast cancer. PATIENTS AND METHODS: A prospective randomized multicentric study was initiated to compare the peritumoral (PT) injection site to the periareolar (PA) site in 449 patients. RESULTS: The detection rate of axillary SLN by lymphoscintigraphy was significantly higher (P = .03) in the PA group (85.2%) than in the PT group (73.2%). Intraoperative detection rate by blue dye and/or gamma probe was similar (99.11%) in both groups. The rate of SLN detection was somewhat higher in the PA group than in the PT group: 95.6% versus 93.8% with blue dye (P = .24) and 98.2% versus 96.0% by probe (P = .16), respectively. The number of SLNs detected by lymphoscintigraphy and by probe was significantly higher in the PA group than in the PT group, 1.5 versus 1.2 (P = .001) and 1.9 versus 1.7 (P = .02). The blue and hot concordance was 95.6% in the PA group and 91.5% in the PT group (P = .08). The mean ex vivo count of the SLN was significantly higher in the PA group than in the PT group (P < .0001). CONCLUSION: This study strongly validates the PA injection technique given the high detection rate (99.1%) of SLN and the high concordance (95.6%) between blue dye and the radiotracer, as well as higher significant ex and in vivo counts, improving SLN probe detection.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colorantes de Rosanilina / Azufre Coloidal Tecnecio Tc 99m / Mastectomía Segmentaria / Radiofármacos / Biopsia del Ganglio Linfático Centinela / Colorantes Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: J Clin Oncol Año: 2007 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colorantes de Rosanilina / Azufre Coloidal Tecnecio Tc 99m / Mastectomía Segmentaria / Radiofármacos / Biopsia del Ganglio Linfático Centinela / Colorantes Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: J Clin Oncol Año: 2007 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos