Efficacy of tamsulosin in the treatment of lower urinary tract symptoms (LUTS) in women.
Asian J Surg
; 30(2): 131-7, 2007 Apr.
Article
en En
| MEDLINE
| ID: mdl-17475584
OBJECTIVE: We attempted to determine whether tamsulosin is an efficacious therapy for the treatment of lower urinary tract symptoms (LUTS) in women. METHODS: A total of 140 women, aged 27-69 years old with LUTS entered a randomized double-blind study comparing tamsulosin (70) versus placebo (70) for 1 month. The outcome variables were mean change from baseline of International Prostate Symptom Score (IPSS), mean change from baseline of mean and maximum urinary flow rate and any adverse effects. RESULTS: Mean change from baseline of IPSS (standard deviation, SD) were -5.6 (6.3) in the tamsulosin group and -2.6 (6.1) in the placebo group. The difference was statistically significant (p = 0.008). Mean change from baseline of mean urinary flow rate (SD) was 0.7 (2.7) mL/second in the tamsulosin group and -0.5 (2.6) mL/second in the placebo group. The difference was also statistically significant (p = 0.013). However, the difference in mean change from baseline of maximum urinary flow rate between the two groups was not statistically significant (p = 0.506). There were two patients in the tamsulosin group who experienced dizziness and asthenia. No other adverse effect was detected. CONCLUSION: Tamsulosin is more efficacious than placebo in the treatment of LUTS in women.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulfonamidas
/
Trastornos Urinarios
/
Antagonistas Adrenérgicos alfa
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Observational_studies
Límite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Asian J Surg
Año:
2007
Tipo del documento:
Article
País de afiliación:
Tailandia
Pais de publicación:
Países Bajos