Effect of addition of hyaluronidase to bupivacaine during axillary brachial plexus block.

Keeler, J F; Simpson, K H; Ellis, F R; Kay, S P

Keeler, J F; Simpson, K H; Ellis, F R; Kay, S P.

Afiliación

Keeler JF; University Department of Anaesthesia, St James's University Hospital, Leeds.

Br J Anaesth ; 68(1): 68-71, 1992 Jan.

Article en En | MEDLINE | ID: mdl-1739571

RESUMEN

We have studied in 22 patients the effect of adding hyaluronidase to bupivacaine during axillary brachial plexus block (BPB) in a double-blind design. Patients received BPB using bupivacaine 2 mg kg-1 with adrenaline 1 in 200,000, either with or without hyaluronidase 3000 iu, in a volume of 0.5 ml per 2.54 cm of the patient's height. The use of hyaluronidase did not increase the speed of onset of anaesthesia or reduce the incidence of inadequate nerve block. Hyaluronidase produced a significant reduction in the duration of anaesthesia. Changes in grip strength and skin temperature were useful in assessing the onset and progress of BPB.

Asunto(s)

Plexo Braquial; Bupivacaína/farmacología; Hialuronoglucosaminidasa/farmacología; Bloqueo Nervioso; Adulto; Anciano; Anciano de 80 o más Años; Bupivacaína/sangre; Método Doble Ciego; Interacciones Farmacológicas; Femenino; Mano/fisiología; Humanos; Masculino; Persona de Mediana Edad; Bloqueo Nervioso/métodos; Sensación/efectos de los fármacos; Temperatura Cutánea/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plexo Braquial / Bupivacaína / Hialuronoglucosaminidasa / Bloqueo Nervioso Tipo de estudio: Clinical_trials Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Anaesth Año: 1992 Tipo del documento: Article Pais de publicación: Reino Unido

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