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Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.
Akritopoulou-Zanze, Irini; Albert, Daniel H; Bousquet, Peter F; Cunha, George A; Harris, Christopher M; Moskey, Maria; Dinges, Jurgen; Stewart, Kent D; Sowin, Thomas J.
Afiliación
  • Akritopoulou-Zanze I; Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA. irini.zanze@abbott.com
Bioorg Med Chem Lett ; 17(11): 3136-40, 2007 Jun 01.
Article en En | MEDLINE | ID: mdl-17391959
We report the synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted kinase inhibitors. Initial efforts focused on the development of selective KDR inhibitors, while later strategies involved the improvement of potency toward multiple kinase targets. Thus, several compounds were identified as potent KDR, Flt1, Flt3, and c-Kit inhibitors.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Proteínas Tirosina Quinasas Receptoras / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Proteínas Tirosina Quinasas Receptoras / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido