[Case report of a rare platelet-specific antigen HPA-10bw allele found in Chinese mainland].
Yi Chuan
; 29(2): 177-9, 2007 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-17369172
A total of 1,000 Chinese blood donors were typed for human platelet antigens (HPA) using a sequence specific primers -polymerase chain reaction (PCR-SSP) based HPA genotyping method. An individual with a rare HPA-10w(a+b+) genotype was found. In order to confirm the typing results, a fragment of HPA-10 gene was amplified by PCR and then sequenced. Sequencing data showed that a single G to A substitution at nucleotide 263 occurred, resulting in amino acid change from Arg(CGA) to Gln(CAA) at position 62 of GPa protein. The substitution generated antigenic specificity HPA-10bw. The detection of an HPA-10bw allele in the Chinese population suggests that this rare allele should be considered in platelet alloimmunization, such as neonatal alloimmune thrombocytopenia (NAIT), post-transfusion thrombocytopenic purpura (PTP) and post-transfusion refractoriness to platelets (PTR).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Plaqueta Humana
/
Polimorfismo de Nucleótido Simple
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China