Dendritic cell immunotherapy for autoimmune diabetes.

Feili-Hariri, Maryam; Flores, Rafael R; Vasquez, A Cecilia; Morel, Penelope A

Feili-Hariri, Maryam; Flores, Rafael R; Vasquez, A Cecilia; Morel, Penelope A.

Afiliación

Feili-Hariri M; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA. haririmf@upmc.edu

Immunol Res ; 36(1-3): 167-73, 2006.

Article en En | MEDLINE | ID: mdl-17337777

RESUMEN

Dendritic cells (DC) play important roles in the initiation of immune responses and maintenance of self-tolerance. We have been studying the role of DC in the pathogenesis of type 1 diabetes and exploring the ability of specific DC subsets to prevent diabetes in non-obese diabetic (NOD) mice. DC subsets that prevent diabetes in this model have a mature phenotype and induce the production of regulatory Th2 cells. We review here recent advances in this area and highlight the importance of optimizing culture conditions and purification methods in the isolation of therapeutic DC.

Asunto(s)

Técnicas de Cultivo de Célula/métodos; Células Dendríticas/inmunología; Diabetes Mellitus Tipo 1/inmunología; Diabetes Mellitus Tipo 1/prevención & control; Inmunoterapia/métodos; Animales; Humanos; Ratones; Ratones Endogámicos NOD

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Dendríticas / Técnicas de Cultivo de Célula / Diabetes Mellitus Tipo 1 / Inmunoterapia Límite: Animals / Humans Idioma: En Revista: Immunol Res Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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