[Treatment of Graves-Basedow's disease with 131I. Assessment of a "modulated fixed activity" protocol]. / Tratamiento de la enfermedad de Graves-Basedow con I. Valoración de un protocolo de "actividades fijas moduladas".
Rev Esp Med Nucl
; 26(1): 3-10, 2007.
Article
en Es
| MEDLINE
| ID: mdl-17286943
PURPOSE: The purpose of this study was to retrospectively evaluate the hypothyroidism rate, persistence of hyperthyroidism and the complications after the administration of 131I in 3 cohorts defined according to the activity of 131I administered. METHODS: We consecutively treated 659 patients diagnosed with Graves-Basedow disease (GBD) with 131I. The activity was determined on the basis of a protocol that we called "modulated fixed activity". A total of 45 patients (Group 1) who had previously undergone surgery were given small 131I activities of between 111-185 MBq (3-5 mCi), 247 patients (Group 2) with normal or almost normal-sized thyroids were given activities of between 222-333 MBq (6-9 mCi) and the 367 patients with diffuse goiters (Group 3) activities of between 370-555 MBq (10-15 mCi). RESULTS: A total of 69.2 % of the patients presented hypothyroidism at the end of the follow-up period. By groups, the percentages of hypothyroidism at the end of the follow-up period were 69 %, 68.8 % and 69.6 % respectively. The average time for the patients to present hypothyroidism was 2.7 years with a maximum de 12.3 years and a minimum of 2 months. No severe precocious complications after the administration of 131I were noted. CONCLUSION: The choice of the modulated fixed doses of 131I for treatment of the GBD is a simple method and permit treatment in only one day.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Graves
/
Radioisótopos de Yodo
Tipo de estudio:
Etiology_studies
/
Guideline
Aspecto:
Patient_preference
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Rev Esp Med Nucl
Asunto de la revista:
MEDICINA NUCLEAR
Año:
2007
Tipo del documento:
Article
Pais de publicación:
España