Structural and functional studies of the corneal endothelium in diabetes mellitus.

Keoleian, G M; Pach, J M; Hodge, D O; Trocme, S D; Bourne, W M

Keoleian, G M; Pach, J M; Hodge, D O; Trocme, S D; Bourne, W M.

Afiliación

Keoleian GM; Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905.

Am J Ophthalmol ; 113(1): 64-70, 1992 Jan 15.

Article en En | MEDLINE | ID: mdl-1728148

RESUMEN

We performed specular microscopy, anterior segment ocular fluorophotometry, corneal pachymetry, and tonometry on 14 patients with chronic type I diabetes and nonproliferative retinopathy and on 14 age-matched control subjects. The eyes of patients with diabetes had an increased coefficient of variation of endothelial cell area, a decreased percentage of hexagonal endothelial cells, increased corneal autofluorescence, and increased intraocular pressure, which confirmed previous studies. There was no difference, however, in corneal thickness or endothelial permeability to fluorescein. Thus, we were unable to detect any abnormality in endothelial function in these diabetic corneas in the unstressed state, despite structurally abnormal endothelial cells.

Asunto(s)

Diabetes Mellitus Tipo 1/fisiopatología; Endotelio Corneal/patología; Endotelio Corneal/fisiopatología; Adulto; Recuento de Células; Permeabilidad de la Membrana Celular; Fluoresceína; Fluoresceínas/farmacocinética; Fluorofotometría; Humanos; Presión Intraocular; Microscopía; Tonometría Ocular

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endotelio Corneal / Diabetes Mellitus Tipo 1 Límite: Adult / Humans Idioma: En Revista: Am J Ophthalmol Año: 1992 Tipo del documento: Article Pais de publicación: Estados Unidos

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