Stable pattern of HIV-1 subtype C Gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected Ethiopians.
AIDS
; 21(3): 369-72, 2007 Jan 30.
Article
en En
| MEDLINE
| ID: mdl-17255746
We studied HIV-1 clade C Gag-specific T-cell responses in five HIV-infected Ethiopians with a relatively slow (< 15 cells/microl per year) and five with a fast (> 45 cells/microl per year) CD4 T-cell decline longitudinally. Six study subjects had T-cell responses directed to one or more HIV-1 Gag peptides. The persistence of strong and broad anti-Gag cytotoxic T-lymphocyte responses was associated with a slow rate of CD4 T-cell decline and with human leukocyte antigen alleles from the B27 supertype.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Productos del Gen gag
/
Infecciones por VIH
/
Subgrupos de Linfocitos T
/
VIH-1
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2007
Tipo del documento:
Article
País de afiliación:
Etiopia
Pais de publicación:
Reino Unido