Room-temperature, phosphorimetric determination of the beta-blocking agent pindolol in pharmaceutical tablets, urine and blood serum.
Anal Bioanal Chem
; 387(5): 1945-8, 2007 Mar.
Article
en En
| MEDLINE
| ID: mdl-17203265
It is already recognised that heavy-atom-induced, room-temperature phosphorescence can be used to determine pindolol in pharmaceutical samples and biological fluids. We describe here a new, simple, rapid and selective development of this technique. The phosphorescence signals derive from the interaction of pindolol with a relatively high concentration of heavy-atom salts in the presence of sodium sulphite as oxygen scavenger. Phosphorescence was registered in the presence of 1.2 M potassium iodide, 15 mM sodium sulphite and 30% v/v methanol at 450 nm, exciting at 285 nm. The detection limit was 21.1 ng mL(-1). The method has been successfully applied to the determination of pindolol in commercial pharmaceutical tablets, urine and blood serum.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pindolol
/
Comprimidos
/
Análisis Químico de la Sangre
/
Urinálisis
/
Mediciones Luminiscentes
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Idioma:
En
Revista:
Anal Bioanal Chem
Año:
2007
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Alemania