The immunohistochemical outline of p27kip1, cyclin B1 and cyclin D3 in pleomorphic adenomas.
Minerva Stomatol
; 55(9): 483-92, 2006 Sep.
Article
en En, It
| MEDLINE
| ID: mdl-17146427
AIM: Pleomorphic adenomas of salivary glands are benign lesions which may sometimes relapse even after complete surgical removal. This risk has led to the search for methods to provide predictive data on the biological behaviour of such neoplasia. The authors intend to evaluate the degree of cellular aggression of these tumours by finding prognostic data using the antigens involved in cellular proliferative activity. Therefore they have chosen for this study: p27kip1, cyclin B1 and Cyclin D3. METHODS: Seventeen mixed tumours, 2 of them relapsed, underwent the direct immunohystochemical PAP technique for the determination of antigens p27kip1, cyclins B1 and D3 of the tissue. RESULTS: The results obtained show that the verification of these markers may reveal a potential risk of biological deviation and that their expression is independent of the degree of cellularity in neoplasias. CONCLUSIONS: On the basis of the results, the conclusion is drawn that there is no relation between the expressivity of the mentioned antigens and histological characters of pleomorphic adenomas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de las Glándulas Salivales
/
Biomarcadores de Tumor
/
Ciclinas
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Adenoma Pleomórfico
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Ciclina B
/
Inhibidor p27 de las Quinasas Dependientes de la Ciclina
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
/
It
Revista:
Minerva Stomatol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Italia