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Protective effect of ethanolic and water extracts of sea buckthorn (Hippophae rhamnoides L.) against the toxic effects of mustard gas.
Vijayaraghavan, R; Gautam, Anshoo; Kumar, Om; Pant, S C; Sharma, Manoj; Singh, Seema; Kumar, H T Satish; Singh, Anand Kumar; Nivsarkar, Manisha; Kaushik, M P; Sawhney, R C; Chaurasia, O P; Prasad, G B K S.
Afiliación
  • Vijayaraghavan R; Defence Research and Development Establishment, Gwalior 474 002, India. vijayjai@sancharnet.in
Indian J Exp Biol ; 44(10): 821-31, 2006 Oct.
Article en En | MEDLINE | ID: mdl-17131913
Ethanolic extract of H. rhamnoides L. leaf (HL-EOH), water and ethanolic extract of H. rhamnoides fruit (HF-W and HF-EOH), and H. rhamnoides flavone from fruit (HR-flavone) were evaluated against percutaneously administered sulphur mustard (SM), a chemical warfare agent. The animals administered with SM (9.7, 19.3 and 38.7 mg/kg) died at various days depending upon the dose and there was a significant reduction in the body weight. The H. rhamnoides extracts (1 g/kg; 3 doses; po) significantly protected the lethality, with a protective index of 2.4, 1.7, 1.7 and 2.2 for HL-EOH, HF-W, HF-EOH and HR-flavone respectively. Reduced glutathione (GSH) and oxidized glutalthione (GSSG) levels were reduced, and malondialdehyde (MDA) was elevated after percutaneous administration of SM. Oral administration of HL-EOH and HR-flavone significantly protected the body weight loss. Recovery in the levels of GSH, GSSG and MDA were also observed following oral administration of HL-EOH and HR-flavone. All the extracts were non-toxic and the LD50 was more than 5 g/kg. The present study shows that percutaneous administration of SM induces oxidative stress and ethanolic extract of leaf of H. rhamnoides and H. rhamnoides flavone from fruit can significantly protect it.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancias para la Guerra Química / Hippophae / Gas Mostaza Límite: Animals Idioma: En Revista: Indian J Exp Biol Año: 2006 Tipo del documento: Article País de afiliación: India Pais de publicación: India
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancias para la Guerra Química / Hippophae / Gas Mostaza Límite: Animals Idioma: En Revista: Indian J Exp Biol Año: 2006 Tipo del documento: Article País de afiliación: India Pais de publicación: India