Constitutive activation of the ERK-MAPK pathway in the suprachiasmatic nuclei inhibits circadian resetting.
FEBS Lett
; 580(28-29): 6665-8, 2006 Dec 11.
Article
en En
| MEDLINE
| ID: mdl-17125769
Circadian entrainment involves photic stimulation of the suprachiasmatic molecular oscillator, including activation of the ERK/MAP kinase, which is phosphorylated endogenously during the day and in response to light during the night. We aimed to disrupt the diurnal cycle of ERK phosphorylation by in vivo transfection of a constitutively active form of MEK, a MAPK kinase. This procedure did not affect normal circadian parameters, but completely inhibited light-induced phase advances. Therefore, circadian regulation of the ERK pathway is not essential for the normal mechanism of the biological clock, but it is fundamental as an interface with environmental entrainment by light.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Núcleo Supraquiasmático
/
Mesocricetus
/
Ritmo Circadiano
/
Proteínas Quinasas Activadas por Mitógenos
/
Quinasas MAP Reguladas por Señal Extracelular
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2006
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Reino Unido