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A chemical study of cyclic depsipeptides produced by a sponge-derived fungus.
Amagata, Taro; Morinaka, Brandon I; Amagata, Akiko; Tenney, Karen; Valeriote, Frederick A; Lobkovsky, Emil; Clardy, Jon; Crews, Phillip.
Afiliación
  • Amagata T; Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA.
J Nat Prod ; 69(11): 1560-5, 2006 Nov.
Article en En | MEDLINE | ID: mdl-17125221
Two novel cyclic depsipeptides, guangomides A (1) and B (2), together with a new destruxin derivative (3) were isolated from the cytotoxic extract obtained from the saltwater culture of an unidentifiable sponge-derived fungus. The new structures were elucidated on the basis of analysis of extensive 1D and 2D NMR data sets, and the absolute configurations of 2S, 9S, 13S, 19S, 24R, 28R of 1 were determined on the basis of the combined X-ray and Marfey's method structure analysis. Identical absolute configurations were assumed for 2. The cytotoxicity of the extract was found to be due to brefeldin A, while 1 and 2 showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depsipéptidos / Hongos / Antibacterianos Límite: Animals Idioma: En Revista: J Nat Prod Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depsipéptidos / Hongos / Antibacterianos Límite: Animals Idioma: En Revista: J Nat Prod Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos