Congenital Chagas disease in Bolivia is not associated with DNA polymorphism of Trypanosoma cruzi.
Am J Trop Med Hyg
; 75(5): 871-9, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-17123980
This study aims to typify the Trypanosoma cruzi (sub)lineage(s) in umbilical cord blood of congenitally infected Bolivian newborns, using PCR amplifications of "Region Markers", mini-exon or kDNA fragments followed by hybridization or sequencing. New probes were also designed to distinguish three variants within the TcIId sublineage. The IIb, IId, or IIe T. cruzi sublineages, as well as different variants of the IId sublineage, were detected in infected neonates, whereas mixed infections were not found. The frequencies of the IId sublineage were similar in neonates (95.1%) and adults of the same area (94.1%). The IId-infected newborns displayed either asymptomatic, or severe and fatal clinical forms of congenital Chagas disease, as well as low or high parasitemia. Altogether these data show that T. cruzi DNA polymorphism, based on the presently available markers, is not associated with the occurrence of congenital infection or the development of severe clinical forms of congenital Chagas disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Trypanosoma cruzi
/
Enfermedad de Chagas
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
País/Región como asunto:
America do sul
/
Bolivia
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
2006
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Estados Unidos