A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting.
Anaesthesia
; 61(11): 1053-7, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-17042842
We conducted a randomised double-blinded study of 960 women undergoing day-case surgery to determine whether combination anti-emetic therapy of granisetron and cyclizine was more effective at decreasing the incidence of postoperative nausea and vomiting than these agents used alone. The women were randomly allocated to three groups to receive intravenous granisetron 1 mg, cyclizine 50 mg or both before induction of general anaesthesia. The incidence of postoperative nausea and vomiting was 77/322 (24%) in the granisetron group, 73/316 (23%) in the cyclizine group and 53/322 (17%) in those women given both drugs (p = 0.04). There was no difference in the requirement for rescue anti-emetic drugs. There were no differences in the anaesthetic techniques used in the three groups. We conclude that the risk of postoperative nausea and vomiting is less with cyclizine and granisetron given together than with either given alone.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Granisetrón
/
Náusea y Vómito Posoperatorios
/
Ciclizina
/
Antieméticos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Anaesthesia
Año:
2006
Tipo del documento:
Article
Pais de publicación:
Reino Unido