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A universal stress protein of Porphyromonas gingivalis is involved in stress responses and biofilm formation.
Chen, Wen; Honma, Kiyonobu; Sharma, Ashu; Kuramitsu, Howard K.
Afiliación
  • Chen W; Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York, NY 14214-3092, USA.
FEMS Microbiol Lett ; 264(1): 15-21, 2006 Nov.
Article en En | MEDLINE | ID: mdl-17020544
Porphyromonas gingivalis is recognized as one of the major periodontal pathogens in subgingival plaque, which is implicated in the progression of chronic periodontal disease. We analyzed the role of upsA in P. gingivalis 381 and its uspA-deficient mutant CW301 under various stress conditions. In general, the uspA mutant was less tolerant to a variety of environmental stresses relative to the parental strain. In addition, gene expression of uspA is upregulated during biofilm formation. Biofilm formation of the uspA mutant was also less than that of strain 381. In conclusion, the uspA gene affecting the stress responses of P. gingivalis is required for optimal biofilm formation.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Porphyromonas gingivalis / Biopelículas / Proteínas de Choque Térmico Idioma: En Revista: FEMS Microbiol Lett Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Porphyromonas gingivalis / Biopelículas / Proteínas de Choque Térmico Idioma: En Revista: FEMS Microbiol Lett Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido