Enhancement of murine cytomegalovirus infection during graft-vs.-host reaction.
J Infect Dis
; 135(6): 990-4, 1977 Jun.
Article
en En
| MEDLINE
| ID: mdl-16972
A mouse model was used for elucidation of the role of a graft-vs-host reaction in promoting cytomegalovirus infection. F1 (DBA/2 X C3H/He) hybrid mice were infected with murine cytomegalovirus. Five weeks later, a graft-vs.-host reaction was produced in the chronically infected animals by the administration of multiple doses of DBA/2 parental splenocytes. Cytomegalovirus was recovered more often from the organs of mice undergoing graft-vs.-host reaction than from those of control animals (P less than 0.001). These results indicate that the graft-vs.-host reaction alone can enhance murine cytomegalovirus infection in a chronically infected host and may help explain the high incidence of cytomegalovirus infection after bone marrow allograft transplantation in man.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Citomegalovirus
/
Modelos Animales de Enfermedad
/
Reacción Injerto-Huésped
Límite:
Animals
Idioma:
En
Revista:
J Infect Dis
Año:
1977
Tipo del documento:
Article
Pais de publicación:
Estados Unidos