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Expression of the myeloid differentiation antigen CD33 depends on the presence of human chromosome 19 in human-mouse hybrids.
Adriaansen, H J; Guerts van Kessel, A H; Wijdenes-de Bresser, J H; van Drunen-Schoenmaker, E; van Dongen, J J.
Afiliación
  • Adriaansen HJ; Department of Immunology, University Hospital Dijkzigt/Erasmus University, Rotterdam, The Netherlands.
Ann Hum Genet ; 54(2): 115-9, 1990 05.
Article en En | MEDLINE | ID: mdl-1696442
Interlineage human-mouse hybrids were constructed by fusion of human acute undifferentiated leukaemia cells with the mouse thymoma cell line BW5147. Some of the hybrids expressed the human differentiation antigens CD4, CD7, CD33, and CD71 (transferrin receptor). Chromosome analysis revealed that the expression of the myeloid antigen CD33 is dependent on the presence of human chromosome 19, which is in agreement with the location of CD33-coding sequences on chromosome 19, as recently reported by Peiper et al. (1987). Furthermore, these hybrids allowed us to confirm the assignment of the CD4 antigen, the CD7 antigen, and the CD71 antigen to human chromosomes 12, 17 and 3, respectively.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 19 / Antígenos de Diferenciación Mielomonocítica / Leucemia / Antígenos CD Límite: Adult / Animals / Humans / Male Idioma: En Revista: Ann Hum Genet Año: 1990 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 19 / Antígenos de Diferenciación Mielomonocítica / Leucemia / Antígenos CD Límite: Adult / Animals / Humans / Male Idioma: En Revista: Ann Hum Genet Año: 1990 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido