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Platelet hyperreactivity generalizes to multiple forms of stimulation.
Yee, D L; Bergeron, A L; Sun, C W; Dong, J-F; Bray, P F.
Afiliación
  • Yee DL; Department of Pediatrics, Hematology-Oncology Section, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
J Thromb Haemost ; 4(9): 2043-50, 2006 Sep.
Article en En | MEDLINE | ID: mdl-16961612
BACKGROUND: Although platelet hyperreactivity constitutes an important cardiovascular risk factor, standardized methods for its measurement are lacking. We recently reported that aggregometry using a submaximal concentration of epinephrine identifies individuals with in vitro platelet hyperreactivity; this hyperreactivity was reproducible on multiple occasions over long periods of time. OBJECTIVE AND METHODS: To better understand this aberrant reactivity, we studied in a large group of subjects (n = 386) the relationship between healthy individuals' platelet reactivity to epinephrine and their platelet phenotype as measured by other functional assays. RESULTS: Subjects with hyperreactivity to epinephrine were more likely to exhibit hyperfunction in each major aspect of platelet activity, including adhesion (response to low-dose ristocetin; P < 0.001), activation (surface P-selectin expression and PAC-1 binding after stimulation; P
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de las Plaquetas Sanguíneas / Activación Plaquetaria / Subunidades beta de la Proteína de Unión al GTP Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Thromb Haemost Asunto de la revista: HEMATOLOGIA Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de las Plaquetas Sanguíneas / Activación Plaquetaria / Subunidades beta de la Proteína de Unión al GTP Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Thromb Haemost Asunto de la revista: HEMATOLOGIA Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido