CSF BACE1 activity is increased in CJD and Alzheimer disease versus [corrected] other dementias.
Neurology
; 67(4): 710-2, 2006 Aug 22.
Article
en En
| MEDLINE
| ID: mdl-16924032
To assess the diagnostic utility of CSF BACE1 activity for discriminating Alzheimer disease (AD) from other dementias, particularly Creutzfeldt-Jakob disease (CJD), the authors studied 26 patients with sporadic CJD, 21 patients with AD, and 21 patients with various non-AD, non-CJD dementias (DCs). CSF BACE1 activity was elevated in AD in comparison with DC (p = 0.01). Unexpectedly, CSF BACE1 activity was also increased in sporadic CJD (p = 0.02).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endopeptidasas
/
Síndrome de Creutzfeldt-Jakob
/
Proteínas 14-3-3
/
Enfermedad de Alzheimer
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Neurology
Año:
2006
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Estados Unidos