Cytokeratins in induced epidermoid formations and cholesteatoma lesions.
Arch Otolaryngol Head Neck Surg
; 116(5): 560-5, 1990 May.
Article
en En
| MEDLINE
| ID: mdl-1691647
The expression of cytokeratins varies with the type of epithelium, the state of differentiation, and pathological conditions. In this study, the differential expression of cytokeratins in external meatal skin and middle ear epithelium was used for a pathogenetic study of cholesteatoma lesions and infection-induced epidermoid formations in the middle ear of the rat. Immunocytochemistry generally revealed an epidermal-type cytokeratin profile in the cholesteatoma matrix, except for the focal expression of nonepidermal cytokeratins at the invasion front. Comparable observations were made in the middle ear of the rat after an infection-induced invasion of epidermal cells from the meatal skin. An infection-induced-cornifying metaplastic lesion of the middle ear epithelium revealed nonepidermal cytokeratin expression. The results of this combined study suggested that the cholesteatoma specimens studied had an epidermal origin. The expression of nonepidermal cytokeratins was considered to result from a state of hyperproliferation rather than from metaplasia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Colesteatoma
/
Enfermedades del Oído
/
Oído Medio
/
Queratinas
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Arch Otolaryngol Head Neck Surg
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
1990
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Estados Unidos