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Freeze-drying of composite core-shell nanoparticles.
Layre, A-M; Couvreur, P; Richard, J; Requier, D; Eddine Ghermani, N; Gref, R.
Afiliación
  • Layre AM; UMR 8612, Faculty of Pharmacy, University of Paris-Sud XI, France.
Drug Dev Ind Pharm ; 32(7): 839-46, 2006 Aug.
Article en En | MEDLINE | ID: mdl-16908421
The effects of four sugars (glucose, saccharose, maltose, trehalose) and one surfactant (Poloxamer 188), on the freeze-drying of poly(isobutylcyanoacrylate) (PIBCA), poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG), and novel core (mainly PIBCA)-shell (principally PEG) composite nanoparticles (CNP) obtained by co-precipitation were investigated. The efficiency of the additives against the adverse effect of freeze-drying on the redispersibility of the nanoparticles was evaluated, based on the visual appearance of the nanoparticle suspensions (Tyndall effect and aggregation), and on the determination of the mean diameter ratio of the nanoparticles before and after freeze-drying. The results indicated that the addition of both sugars and surfactant was essential for the good redispersion of freeze-dried nanoparticles displaying hydrophobic (PIBCA) or hydrophilic (PCL-PEG and CNP) surfaces.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Composición de Medicamentos / Nanopartículas Idioma: En Revista: Drug Dev Ind Pharm Año: 2006 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Composición de Medicamentos / Nanopartículas Idioma: En Revista: Drug Dev Ind Pharm Año: 2006 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido