[A new dimension of DNA analysis: genomic profiling by matrix CGH]. / Genomanalysen menschlicher Tumoren mittels Matrix-CGH.
Verh Dtsch Ges Pathol
; 87: 165-71, 2003.
Article
en De
| MEDLINE
| ID: mdl-16888909
Analysis of genetic alterations in tumor cells represent a first step to understand the molecular mechanism of cancer etiology and development. Due to the progress in genome research, it is feasible to assess the complexity of genomic changes on a large scale. Protocols for gene expression profiling using cDNA arrays have been developed allowing to test the activity of almost all human genes in tumor cells. Another important approach is matrix-CGH which was recently developed to assess gains and losses on the genomic level with high resolution. This method not only allows to narrow down the position of novel oncogenes or tumor suppressor-genes but also contributes to a refinement of tumor classifications. Since matrix-CGH can be performed under highly standardized conditions in a fully automatized way, it is suited for diagnostics in clinical laboratories.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN de Neoplasias
/
Perfilación de la Expresión Génica
/
Neoplasias
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
De
Revista:
Verh Dtsch Ges Pathol
Año:
2003
Tipo del documento:
Article
Pais de publicación:
Alemania