Effects of beta-blockade on urinary albumin excretion in normal subjects.
Int J Clin Pharmacol Res
; 11(6): 271-4, 1991.
Article
en En
| MEDLINE
| ID: mdl-1688052
Urinary albumin excretion is a marker of renal damage in diabetic or hypertensive patients and a reduction of albuminuria during beta-blockade has been demonstrated in several studies. In the present study the effects of beta-blockade with drugs known for differences in their impact on renal function (propranolol, atenolol, bopindolol) on albumin excretion in normotensive and normoalbuminuric subjects were investigated. No effect of beta-blockade on albumin excretion was found, despite decreased plasma renin activity, blood pressure and heart rate. It was concluded that studies in healthy controls are not useful to predict the outcome of treatment in microalbuminuric patients. Cross-over studies using different beta-blockers have yet to be done in micro- or macroalbuminuric patients to evaluate the potential for benefit.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antagonistas Adrenérgicos beta
/
Albuminuria
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Int J Clin Pharmacol Res
Año:
1991
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Suiza