Genotyping of human cystic echinococcosis in Xinjiang, PR China.
Parasitology
; 133(Pt 5): 571-9, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-16836793
The Xinjiang Uygur Autonomous Region, multi-ethnic province in northwestern China, is one of the most important foci of human cystic echinococcosis (CE) in the world. Two Echinococcus granulosus genotypes (G1 and G6) are known to infect the intermediate hosts in this area but, to date, the source of the human infection remains unclear. The current study aimed to genetically analyse 67 hydatid cysts removed from 47 CE patients for which epidemiological, clinical and serological data were also recorded. Mitochondrial cox 1 gene sequencing suggested that the E. granulosus G1 genotype is the major source of infection (45/47 CE patients). Nevertheless, for the first time in China, 2 patients were found with hydatid cysts of the G6 genotype. In addition, 45 E. granulosus gravid tapeworms, isolated from 13 dogs, were genotyped. The majority of adult worms (42/45) exhibited the G1 genotype, whereas 3 adult tapeworms with the G6 genotype were found in one dog, that also harboured E. granulosus tapeworms of the G1 genotype. This sympatric occurrence of G1 and G6 genotypes of E. granulosus, not only in the same area but also in the same definitive host, raises the interesting question of putative genetic recombination between these E. granulosus genotypes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Echinococcus granulosus
/
Enfermedades de los Perros
/
Equinococosis
Límite:
Adolescent
/
Adult
/
Aged
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Animals
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Child
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Child, preschool
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Humans
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Parasitology
Año:
2006
Tipo del documento:
Article
Pais de publicación:
Reino Unido