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Early pathologic findings and long-term improvement in anti-Ma2-associated encephalitis.
Blumenthal, D T; Salzman, K L; Digre, K B; Jensen, R L; Dunson, W A; Dalmau, J.
Afiliación
  • Blumenthal DT; Department of Neurology, Oncology Huntsman Cancer Institute, University of Utah, Salt Lake City, USA.
Neurology ; 67(1): 146-9, 2006 Jul 11.
Article en En | MEDLINE | ID: mdl-16832096
A 67-year-old man sequentially developed anti-Ma2-associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-associated protein TIA-1 and the membranolytic protein granzyme-B. Although recovery was thought to be unlikely, treatment of the PNE with corticosteroids and resection of the associated lung cancer resulted in dramatic improvement for 21 months.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalitis / Antígenos de Neoplasias / Proteínas del Tejido Nervioso Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: Neurology Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalitis / Antígenos de Neoplasias / Proteínas del Tejido Nervioso Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: Neurology Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos