Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells.
Proc Natl Acad Sci U S A
; 88(22): 10129-33, 1991 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-1682923
We recently showed that hemopoietic stem cells expressing the v-abl oncogene can cause leukemia when injected into lethally irradiated recipient mice. Progenitor cells expressing v-abl did not significantly contribute to disease development, and the leukemia was monoclonal in origin. By serially transplanting v-abl-transduced hemopoietic stem cells into normal, nonirradiated syngeneic recipients, we showed that multiple stem-cell clones do exist in some recipients. These cells fluctuated as normal stem cells do and could home to normal bone marrow. Based on the time course of disease, the recipients developed either an acute or a chronic phase of disorder. All recipients with the acute disease had stem-cell clones with random Abelson murine leukemia virus integration sites. All recipients with the chronic disorder had a specific Abelson murine leukemia virus integration site. We believe this abl-specific integration site, termed ASI, is important in abl-mediated stem-cell leukemogenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Leucemia Murina de Abelson
/
Células Madre Hematopoyéticas
/
Leucemia Experimental
/
Trastornos Mieloproliferativos
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Estados Unidos