Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos.

Ramírez-Anguiano, Jaqueline; Yamamoto-Furusho, Jesús K; Barquera, Rodrigo; Beltrán, Olga; Granados, Julio

Ramírez-Anguiano, Jaqueline; Yamamoto-Furusho, Jesús K; Barquera, Rodrigo; Beltrán, Olga; Granados, Julio.

Afiliación

Ramírez-Anguiano J; Department of Otolaryngology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Privada de San Francisco No. 47-1 Barrio San Francisco, San Jerónimo Magdalena Contreras, CP 10810, Mexico City DF, Mexico. jmdelafuente@hotmail.com

Otolaryngol Head Neck Surg ; 135(1): 90-3, 2006 Jul.

Article en En | MEDLINE | ID: mdl-16815190

RESUMEN

OBJECTIVE: The pathogenesis of sinonasal polyposis (SNP) is not clear; it has been suggested that it is polygenic and multifactorial. The major histocompatibility complex is a useful tool to predict genetic susceptibility to diseases, especially to autoimmune diseases. Since such susceptibility is influenced by ethnicity, it is necessary to have a wide knowledge of the structure of the population to which the patient belongs. The purpose of the study was to determine the association of HLA-DRB1 alleles with sinonasal polyposis in the Mexican Mestizo population. STUDY DESIGN: We studied the HLA-DR alleles in 34 adult Mexican Mestizo patients with SNP and compared them to those present in 99 healthy controls. METHODS: Genomic DNA from mononuclear cells was obtained by using the "salting out" technique and high-resolution DNA typing of the HLA-DRB1 alleles was performed after PCR amplification. RESULTS: We found a statistically significant increased frequency of the HLA-DRB1*03 allele (P = 0.03, odds ratio [OR] = 2.9, 95% confidence interval [CI]: 1.0-7.8) and of the HLA-DRB1*04 allele (P = 0.009, OR = 2.2, 95% CI: 1.2-4.2) in patients with SNP as compared to controls, and a statistically significant decreased frequency of the HLA-DRB1*08 allele (P = 0.01, OR = 0.2, 95% CI: 0.05-0.8). CONCLUSION: The HLA-DR locus seems to be associated with the genetic susceptibility to develop SNP in Mexicans. EBM RATING: B-2b.

Asunto(s)

ADN/genética; Expresión Génica; Antígeno HLA-DR3/genética; Antígeno HLA-DR4/genética; Pólipos Nasales; Adulto; Anciano; Alelos; Femenino; Frecuencia de los Genes; Humanos; Incidencia; Masculino; México/etnología; Persona de Mediana Edad; Pólipos Nasales/etnología; Pólipos Nasales/genética; Pólipos Nasales/inmunología; Reacción en Cadena de la Polimerasa; Estudios Retrospectivos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Expresión Génica / Antígeno HLA-DR3 / Antígeno HLA-DR4 / Pólipos Nasales Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Mexico Idioma: En Revista: Otolaryngol Head Neck Surg Año: 2006 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido

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