[Proteome analysis--basis for individualized pancreatic carcinoma therapy?]. / Proteomanalyse. Basis für individualisierte Pankreaskarzinomtherapie?
Internist (Berl)
; 47 Suppl 1: S40-8, 2006 Jun.
Article
en De
| MEDLINE
| ID: mdl-16773365
Ductal pancreatic adenocarcinoma is a dismal disease, having the worst prognosis of all solid tumors. While genomics and transcriptomics have provided a wealth of data, no contribution has been made to clinical medicine in terms of diagnostic or prognostic markers. Hope lies in yet another novel technology, proteomics. Conceptually, proteomics bears the advantage of incorporating both posttranslational modifications as well as host factors. This is thought to be important in factors influencing survival such as chemoresistance. This tutorial review discusses the state of the art in pancreatic cancer proteomics in light of technical developments. At this moment, proteomics is still at the beginning in clinical application. First results, however, suggest some hope for the development of a new understanding of the molecular biology in pancreatic cancer yielding into very specific markers of disease or allowing a rational and individualized therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Adenocarcinoma
/
Biomarcadores de Tumor
/
Proteoma
/
Perfilación de la Expresión Génica
/
Proteínas de Neoplasias
Tipo de estudio:
Prognostic_studies
Idioma:
De
Revista:
Internist (Berl)
Año:
2006
Tipo del documento:
Article
Pais de publicación:
Alemania