Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.

Minhas, Gurpreet Singh; Pilch, Daniel S; Kerrigan, John E; LaVoie, Edmond J; Rice, Joseph E

Minhas, Gurpreet Singh; Pilch, Daniel S; Kerrigan, John E; LaVoie, Edmond J; Rice, Joseph E.

Afiliación

Minhas GS; Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

Bioorg Med Chem Lett ; 16(15): 3891-5, 2006 Aug 01.

Article en En | MEDLINE | ID: mdl-16735121

RESUMEN

The synthesis of 24-membered macrocycles containing four, six, and seven oxazole moieties is described. Selected compounds were evaluated for their ability to specifically bind and stabilize G-quadruplex DNA and for cytotoxic activity. An unexpected oxidative cleavage reaction afforded a macrocyclic imide that was also evaluated for G-quadruplex stabilizing and cytotoxic activity.

Asunto(s)

ADN/química; Compuestos Macrocíclicos/síntesis química; Oxazoles/química; Compuestos Macrocíclicos/química; Espectrofotometría Ultravioleta

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazoles / ADN / Compuestos Macrocíclicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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