Studies on the thymus in Chagas' disease. II. Thymocyte subset fluctuations in Trypanosoma cruzi-infected mice: relationship to stress.
Scand J Immunol
; 33(3): 267-75, 1991 Mar.
Article
en En
| MEDLINE
| ID: mdl-1672774
Changes in thymic T-cell subsets in mice acutely infected with Trypanosoma cruzi have been studied in both C3H/HeJ and C57BL/6 mice. The significant decrease in thymocyte number, observed in both mouse strains on day 14 post-infection correlated with a drastic decrease in CD4+CD8+ cell number, whereas the number of CD4-CD8-, CD4+CD8- and CD4-CD8+ cells remained essentially unchanged. The important increase in CD3hi cell frequency confirmed that resistant thymocytes during Chagas' disease development were mostly medullary thymocytes, whereas the thymic cortex was largely depleted, as previously observed on thymus sections. This involution of the thymus could have been due to the increase of circulating glucocorticoid levels observed after infection. However, similar cell modifications were found in infected adrenalectomized mice whose serum corticosterone levels were only slightly augmented. Thus, the thymic alterations appear not to be linked to stress responses, at least those dependent on high levels of circulating glucocorticoids.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Timo
/
Subgrupos de Linfocitos T
/
Enfermedad de Chagas
Límite:
Animals
Idioma:
En
Revista:
Scand J Immunol
Año:
1991
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido