Structure and visualization of high-dimensional conductance spaces.
J Neurophysiol
; 96(2): 891-905, 2006 Aug.
Article
en En
| MEDLINE
| ID: mdl-16687617
Neurons, and realistic models of neurons, typically express several different types of voltage-gated conductances. These conductances are subject to continual regulation. Therefore it is essential to understand how changes in the conductances of a neuron affect its intrinsic properties, such as burst period or delay to firing after inhibition of a particular duration and magnitude. Even in model neurons, it can be difficult to visualize how the intrinsic properties vary as a function of their underlying maximal conductances. We used a technique, called clutter-based dimension reordering (CBDR), which enabled us to visualize intrinsic properties in high-dimensional conductance spaces. We applied CBDR to a family of models with eight different types of voltage- and calcium-dependent channels. CBDR yields images that reveal structure in the underlying conductance space. CBDR can also be used to visualize the results of other types of analysis. As examples, we use CBDR to visualize the results of a connected-components analysis, and to visually evaluate the results of a separating-hyperplane (i.e., linear classifier) analysis. We believe that CBDR will be a useful tool for visualizing the conductance spaces of neuronal models in many systems.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Modelos Neurológicos
/
Conducción Nerviosa
/
Neuronas
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos