[Circadian rhythms in cartilage].

Kato, Yukio; Kawamoto, Takeshi; Honda, Kiyomasa K

Kato, Yukio; Kawamoto, Takeshi; Honda, Kiyomasa K.

Afiliación

Kato Y; Hiroshima University, Graduate School of Biomedical Sciences, Department of Dental and Medical Biochemistry.

Clin Calcium ; 16(5): 838-45, 2006 May.

Article en Ja | MEDLINE | ID: mdl-16679627

RESUMEN

Circadian rhythms in cartilage have been reported repeatedly. However, previous studies used histological analysis or radioisotope-labeled precursors for DNA, collagen and proteoglycan synthesis, and thus it is difficult precisely to evaluate such studies on circadian rhythms in chondrocytes. On the other hand, circadian rhythms in plasma levels of several hormones, which play crucial roles in cartilage metabolism, proved to be significant both in human and animal models. In addition, clock genes--such as Clock, Bmal, Per, Cry and Dec--were identified in suprachiasmatic nucleus (SCN) and some peripheral tissues. These clock genes may be involved in circadian rhythms in cartilage.

Asunto(s)

Cartílago/metabolismo; Ritmo Circadiano/genética; Ritmo Circadiano/fisiología; Animales; Proteínas CLOCK; División Celular/genética; Condrocitos/citología; Colágeno/biosíntesis; ADN/biosíntesis; Humanos; Proteoglicanos/biosíntesis; Transactivadores/fisiología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago / Ritmo Circadiano Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: Ja Revista: Clin Calcium Asunto de la revista: METABOLISMO Año: 2006 Tipo del documento: Article Pais de publicación: Japón

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