Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathways.
Neuroscience
; 141(1): 101-8, 2006 Aug 11.
Article
en En
| MEDLINE
| ID: mdl-16677772
Astrocytes are thought to be critical to neurons' surviving damage caused by ischemic stroke or other injury. Plasminogen activator inhibitor-1 is one of the active soluble factors released by astrocytes and regulates plasminogen activator-plasmin proteolytic sequence in the CNS as a serpin. In this study, we show that plasminogen activator inhibitor-1 can promote neurite outgrowth and survival of rat pheochromocytoma cells in serum-deprived conditions, and that this neuroprotective activity is correlated with enhanced activation of both extracellular signal-regulated kinases following a direct phosphorylation of nerve growth factor receptor, Trk A, and of c-Jun. Our results suggest that plasminogen activator inhibitor-1 can act as a neurotrophic factor, protecting neurons from serum deprivation-induced neuron death not only by compensating for nerve growth factor functions, but also by activating the c-Jun/activating protein-1 pathway.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inhibidores de Serina Proteinasa
/
Diferenciación Celular
/
Proteínas Proto-Oncogénicas c-jun
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Inhibidor 1 de Activador Plasminogénico
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Factor de Crecimiento Nervioso
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Quinasas MAP Reguladas por Señal Extracelular
Límite:
Animals
Idioma:
En
Revista:
Neuroscience
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos