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Cloning of rhesus monkey LILRs.
Slukvin, I I; Grendell, R L; Rao, D S; Hughes, A L; Golos, T G.
Afiliación
  • Slukvin II; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA. islukvin@wisc.edu
Tissue Antigens ; 67(4): 331-7, 2006 Apr.
Article en En | MEDLINE | ID: mdl-16634871
Leukocyte Ig-like receptors (LILRs) are a family of receptors that have inhibitory and activating functions and widely expressed by lymphoid and myeloid cells. Here we report the identification of the rhesus monkey LILRs by screening of rhesus spleen and decidua cDNA libraries and RT-PCR cloning. We obtained eight different full-length clones with structural and functional diversity similar to human LILRs, including LILRs with immunoreceptor tyrosine-based inhibitory motifs, LILRs with truncated cytoplasmic tails containing positively charged arginine residues in the transmembrane domain, and putative soluble receptors lacking transmembrane or cytoplasmic domains. Characterization of rhesus LILRs will facilitate use of this non-human primate model for the study of the functional role(s) of LILRs, including immune regulation through interaction with non-classical MHC class I molecules.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Inmunológicos / Macaca mulatta Límite: Animals Idioma: En Revista: Tissue Antigens Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Inmunológicos / Macaca mulatta Límite: Animals Idioma: En Revista: Tissue Antigens Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido