Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene: an unexpected chelating effect.

Yu, Chung-Shan; Chiang, Li-Wu; Wu, Chien-Hung; Wang, Ren-Tsong; Chen, Shao-Wei; Wang, Heng-Yen; Yeh, Chien-Hung

Yu, Chung-Shan; Chiang, Li-Wu; Wu, Chien-Hung; Wang, Ren-Tsong; Chen, Shao-Wei; Wang, Heng-Yen; Yeh, Chien-Hung.

Afiliación

Yu CS; Department of Nuclear Science, National Tsing-Hua University, Hsinchu 300, Taiwan. csyu@mx.nthu.edu.tw

Nucl Med Biol ; 33(3): 367-70, 2006 Apr.

Article en En | MEDLINE | ID: mdl-16631085

RESUMEN

Tumor cells transduced with herpes simplex virus thymidine kinase gene has been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facial preparation of 5-[125I]iodoarabinosyl uridine starting from commercial available uridine is reported herein. Interestingly, the tin group in 5-trimethylstannyl arabinosyluridine was easily removed during purification. The destannylation through the formation of a six-ligand coordination involving 2'-hydroxyl and tin was thereby proposed.

Asunto(s)

Arabinofuranosil Uracilo/síntesis química; Genes Virales; Radioisótopos de Yodo; Simplexvirus/enzimología; Timidina Quinasa/genética; Quelantes; Humanos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arabinofuranosil Uracilo / Timidina Quinasa / Simplexvirus / Genes Virales / Radioisótopos de Yodo Límite: Humans Idioma: En Revista: Nucl Med Biol Asunto de la revista: BIOLOGIA / MEDICINA NUCLEAR Año: 2006 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos

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