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Bovine lactoferrin for Helicobacter pylori eradication: an open, randomized, multicentre study.
Di Mario, F; Aragona, G; Dal Bó, N; Cavallaro, L; Marcon, V; Olivieri, P; Benedetti, E; Orzès, N; Marin, R; Tafner, G; Chilovi, F; De Bastiani, R; Fedrizzi, F; Franceschi, M; Salvat, M H; Monica, F; Piazzi, L; Valiante, F; Vecchiati, U; Cavestro, G M; Comparato, G; Iori, V; Maino, M; Leandro, G; Pilotto, A; Rugge, M; Franzè, A.
Afiliación
  • Di Mario F; Gastroenterology, University of Parma, Parma, Italy. francesco.dimario@unipr.it
Aliment Pharmacol Ther ; 23(8): 1235-40, 2006 Apr 15.
Article en En | MEDLINE | ID: mdl-16611285
BACKGROUND: Cure rates for eradication of Helicobacter pylori appear to be decreasing, thus more effective therapies must be identified. AIM: To evaluate the efficacy of bovine lactoferrin in the treatment of H. pylori infection. METHODS: In a multicentered prospective study, 402 (mean age 52.4, range 19-84 years) H. pylori-positive patients were assigned to one of three regimens: group A - esomeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. for 7 days; group B - lactoferrin 200 mg b.d. for 7 days followed by the same schedule of group A; group C - esomeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. plus lactoferrin 200 mg b.d. for 7 days. RESULTS: Of the 402 patients, 389 completed the study. Six patients were discontinued due to side effects, one patient in group B died and six patients were lost to follow up. The eradication rate (intention-to-treat analysis) was 77% in group A (105/136), 73% in group B (97/132) and 90% in group C (120/134) (chi(2)-test P < 0.01). The incidence of side effects was 9.5% in group A, 9% in group B and 8.2% in group C (chi(2)-test P = 0.1). CONCLUSION: This study demonstrates that bovine lactoferrin is an effective adjuvant to 7-day triple therapy for eradication of H. pylori infection.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Lactoferrina / Antibacterianos Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Aliment Pharmacol Ther Asunto de la revista: FARMACOLOGIA / GASTROENTEROLOGIA / TERAPIA POR MEDICAMENTOS Año: 2006 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Lactoferrina / Antibacterianos Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Aliment Pharmacol Ther Asunto de la revista: FARMACOLOGIA / GASTROENTEROLOGIA / TERAPIA POR MEDICAMENTOS Año: 2006 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido