Body weights and plasma prolactin levels in female rats treated subchronically with ziprasidone versus olanzapine.

Kalinichev, Mikhail; Rourke, Claire; Jones, Declan N C

Kalinichev, Mikhail; Rourke, Claire; Jones, Declan N C.

Afiliación

Kalinichev M; Schizophrenia and Bipolar Disorders - In Vivo Biology, Psychiatry CEDD, GlaxoSmithKline PLC, New Frontiers Science Park, Harlow, Essex, UK. mikhail.m.kalinichev@gsk.com

Behav Pharmacol ; 17(3): 289-92, 2006 May.

Article en En | MEDLINE | ID: mdl-16572006

RESUMEN

In a putative animal model of antipsychotic drug-induced weight gain, female rats received either vehicle, ziprasidone (2.0, 6.0, 10 mg/kg) or olanzapine (2.0 mg/kg), orally, twice daily, for 7 days. Body weights were assessed daily and prolactin assayed at the end of the regimen. Ziprasidone caused significant weight gain, as did olanzapine, while stimulating distinct patterns of prolactin secretion. Thus, assessment of body weight provides only limited predictive validity in differentiating between weight gain-inducing and weight-neutral drugs.

Asunto(s)

Antipsicóticos/farmacología; Peso Corporal/efectos de los fármacos; Piperazinas/farmacología; Prolactina/sangre; Tiazoles/farmacología; Animales; Benzodiazepinas/farmacología; Femenino; Olanzapina; Ratas; Ratas Sprague-Dawley; Aumento de Peso/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Prolactina / Tiazoles / Antipsicóticos / Peso Corporal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Behav Pharmacol Asunto de la revista: CIENCIAS DO COMPORTAMENTO / FARMACOLOGIA Año: 2006 Tipo del documento: Article Pais de publicación: Reino Unido

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