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The influence of H1-, H2- and H3-receptors on the spontaneous and ConA induced histamine release from human adenoidal mast cells.
Bent, S; Fehling, U; Braam, U; Schunack, W; Schmutzler, W.
Afiliación
  • Bent S; Institut für Pharmakologie und Toxikologie, Medizinische Fakultät der RWTH Aachen.
Agents Actions ; 33(1-2): 67-70, 1991 May.
Article en En | MEDLINE | ID: mdl-1654736
The effects of the H3-agonist R-alpha-methylhistamine (R-alpha-MeHA) and the H3-antagonist thioperamide on the spontaneous and concanavalin A (ConA) induced histamine release from human mast cells were tested and compared with the effect of some H1- and H2-receptor active substances. R-alpha-MeHA (10(-9)-10(-7) M) exerted no effect on histamine release whereas thioperamide increased the spontaneous release at 10(-6)-10(-4) M but inhibited the ConA induced release in a narrow concentration range (10(-6)-10(-5) M). This enhancement might be taken as an indication of the existence of H3-receptor dependent autoregulation although presently other mechanism cannot be excluded.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Histamínicos / Tonsila Faríngea / Concanavalina A / Mastocitos Límite: Humans Idioma: En Revista: Agents Actions Año: 1991 Tipo del documento: Article Pais de publicación: Suiza
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Histamínicos / Tonsila Faríngea / Concanavalina A / Mastocitos Límite: Humans Idioma: En Revista: Agents Actions Año: 1991 Tipo del documento: Article Pais de publicación: Suiza