[Characterization of epidemic influenza virus A(H3N2) strains circulating in Russia in the 2003-2004 epidemic season].

Ivanova, V T; Burtseva, E I; Slepushkin, A N; Shchelkanov, M Iu; Zagorskaia, Iu V; Shevchenko, E S; Rakutina, R O; Cherkasov, E G; Isaeva, E I; Oskerko, T A; Feodoritova, E L; Maslov, D V; Gatich, R Z

Ivanova, V T; Burtseva, E I; Slepushkin, A N; Shchelkanov, M Iu; Zagorskaia, Iu V; Shevchenko, E S; Rakutina, R O; Cherkasov, E G; Isaeva, E I; Oskerko, T A; Feodoritova, E L; Maslov, D V; Gatich, R Z.

Vopr Virusol ; 51(1): 19-23, 2006.

Article en Ru | MEDLINE | ID: mdl-16515037

RESUMEN

Studies indicated that the epidemic rise in the incidence of influenza was caused by its virus A (H3N2) circulation in Russia in the 2003-2004 season. The Center of Influenza Ecology and Epidemiology investigated 101 epidemic strains isolated the MDCK culture. Antigenic analysis showed that all viruses A(H3N2) were similar to the reference virus A/Fujian/411/02(H3N2) and only 5 strains slightly differed from the latter. Twelve (14%) strains resistant to rimantadine at a concentration of 0.5 mg/ml were identified. Investigation of paired sera from the patients demonstrated a rise of antibodies to the references of influenza virus A(H3N2) in 68.7% of cases and a less increase in those to influenza viruses A(H1N1) and B. The active circulation of A(H3N2) viruses was due not only to changes in their antigenic structure, but also to the low level of antibodies to these viruses, as shown by the analysis of donor sera.

Asunto(s)

Donantes de Sangre; Subtipo H3N2 del Virus de la Influenza A/clasificación; Gripe Humana/virología; Adolescente; Adulto; Anciano; Animales; Anticuerpos Antivirales/sangre; Anticuerpos Antivirales/inmunología; Especificidad de Anticuerpos; Antígenos Virales/inmunología; Antivirales/farmacología; Línea Celular; Niño; Preescolar; Farmacorresistencia Viral; Humanos; Subtipo H1N1 del Virus de la Influenza A/inmunología; Subtipo H3N2 del Virus de la Influenza A/efectos de los fármacos; Subtipo H3N2 del Virus de la Influenza A/inmunología; Gripe Humana/sangre; Persona de Mediana Edad; Rimantadina/farmacología; Federación de Rusia; Especificidad de la Especie

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Sangre / Gripe Humana / Subtipo H3N2 del Virus de la Influenza A Límite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Humans / Middle aged País/Región como asunto: Asia / Europa Idioma: Ru Revista: Vopr Virusol Año: 2006 Tipo del documento: Article Pais de publicación: Rusia

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