Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats.

Wainstok de Calmanovici, R; Cochón, A C; Zenklusen, J C; Aldonatti, C; Cabral, J R; San Martín de Viale, L C

Wainstok de Calmanovici, R; Cochón, A C; Zenklusen, J C; Aldonatti, C; Cabral, J R; San Martín de Viale, L C.

Afiliación

Wainstok de Calmanovici R; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.

Cancer Lett ; 58(3): 225-32, 1991 Jul 04.

Article en En | MEDLINE | ID: mdl-1649694

RESUMEN

The response of female BDVI rats bearing diethylnitrosamine(DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins although the surrounding liver accumulated more porphyrins than livers treated with HCB. (3) DENA/HCB livers which developed a well defined tumor showed slightly less porphyrinogen carboxylyase inhibition and delta-aminolaevulinate synthase induction than HCB rats. (4) The results of the present work suggest that endogenously formed porphyrins would be unable to be accumulated by DENA-induced tumors when the tumoral development precedes the onset of the porphyria.

Asunto(s)

Carcinoma Hepatocelular/complicaciones; Dietilnitrosamina/farmacología; Hexaclorobenceno/farmacología; Neoplasias Hepáticas/complicaciones; Porfirias/metabolismo; 5-Aminolevulinato Sintetasa/metabolismo; Ácido Aminolevulínico/orina; Animales; Carcinoma Hepatocelular/inducido químicamente; Carcinoma Hepatocelular/metabolismo; Sistema Enzimático del Citocromo P-450/metabolismo; Femenino; Ferroquelatasa/metabolismo; Hígado/metabolismo; Neoplasias Hepáticas/inducido químicamente; Neoplasias Hepáticas/metabolismo; Porfobilinógeno/orina; Porfirias/etiología; Porfirinas/metabolismo; Ratas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Porfirias / Carcinoma Hepatocelular / Dietilnitrosamina / Hexaclorobenceno / Neoplasias Hepáticas Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Cancer Lett Año: 1991 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Irlanda

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