Donor kidney volume and outcomes following live donor kidney transplantation.

Poggio, E D; Hila, S; Stephany, B; Fatica, R; Krishnamurthi, V; del Bosque, C; Goldfarb, D; Herts, B; Dennis, V W; Heeger, P S; Braun, W

Poggio, E D; Hila, S; Stephany, B; Fatica, R; Krishnamurthi, V; del Bosque, C; Goldfarb, D; Herts, B; Dennis, V W; Heeger, P S; Braun, W.

Afiliación

Poggio ED; Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cleveland, Ohio, USA. poggioe@ccf.org

Am J Transplant ; 6(3): 616-24, 2006 Mar.

Article en En | MEDLINE | ID: mdl-16468974

RESUMEN

Pre-donation kidney volume and function may be crucial factors in determining graft outcomes in kidney transplant recipients. We measured living donor kidney volumes by 3D helical computed tomography scanning and glomerular filtration rate (GFR) by (125)I-iothalamate clearances in 119 donors, and correlated these values with graft function and incidence of acute rejection at 2 years post-transplantation. Kidney volume strongly correlated with GFR (Pearson r= 0.71, p < 0.001). Body size and male gender were independent correlates of larger kidney volumes, and body size and age were predictors of kidney function. The effects of transplanted kidney volume on graft outcome were studied in 104 donor-recipient pairs. A transplanted kidney volume greater than 120 cc/1.73 m(2) was independently associated with better estimated GFR at 2 years post-transplant when compared to recipients of lower transplanted kidney volumes (64 +/- 19 vs. 48 +/- 14 mL/min/1.73 m(2), p < 0.001). Moreover, recipients of lower volumes had a higher incidence of acute cellular rejection (16% vs. 3.7%, p = 0.046). In conclusion, kidney volume strongly correlates with function in living kidney donors and is an independent determinant of post-transplant graft outcome. The findings suggest that (1) transplantation of larger kidneys confers an outcome advantage and (2) larger kidneys should be preferred when selecting from otherwise similar living donors.

Asunto(s)

Trasplante de Riñón/métodos; Riñón/diagnóstico por imagen; Donadores Vivos; Adulto; Femenino; Tasa de Filtración Glomerular; Rechazo de Injerto/epidemiología; Humanos; Incidencia; Riñón/fisiopatología; Masculino; Persona de Mediana Edad; Tamaño de los Órganos; Estudios Retrospectivos; Tomografía Computarizada por Rayos X; Resultado del Tratamiento

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Donadores Vivos / Riñón Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links