5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis.

Upcroft, Jacqueline A; Dunn, Linda A; Wright, Janelle M; Benakli, Kamel; Upcroft, Peter; Vanelle, Patrice

Upcroft, Jacqueline A; Dunn, Linda A; Wright, Janelle M; Benakli, Kamel; Upcroft, Peter; Vanelle, Patrice.

Afiliación

Upcroft JA; The Queensland Institute of Medical Research and ACITHN, P.O. Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Jacqui.Upcroft@qimr.edu.au

Antimicrob Agents Chemother ; 50(1): 344-7, 2006 Jan.

Article en En | MEDLINE | ID: mdl-16377707

RESUMEN

Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.

Asunto(s)

Antiprotozoarios/farmacología; Giardia lamblia/efectos de los fármacos; Metronidazol/farmacología; Nitroimidazoles/farmacología; Trichomonas vaginalis/efectos de los fármacos; Animales; Resistencia a Medicamentos; Peso Molecular; Relación Estructura-Actividad

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trichomonas vaginalis / Giardia lamblia / Metronidazol / Nitroimidazoles / Antiprotozoarios Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2006 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos

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