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Neuropsychological function in high-risk breast cancer survivors after stem-cell supported high-dose therapy versus standard-dose chemotherapy: evaluation of long-term treatment effects.
Scherwath, A; Mehnert, A; Schleimer, B; Schirmer, L; Fehlauer, F; Kreienberg, R; Metzner, B; Thiel, E; Zander, A R; Schulz-Kindermann, F; Koch, U.
Afiliación
  • Scherwath A; Institute of Medical Psychology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany. a.scherwath@uke.uni-hamburg.de
Ann Oncol ; 17(3): 415-23, 2006 Mar.
Article en En | MEDLINE | ID: mdl-16357023
BACKGROUND: Studies on cognitive functioning in breast cancer patients point out that a subset of women exhibit chemotherapy-related neuropsychological impairment. Thereby, high-dose therapy may elevate the risk of cognitive dysfunctions. The primary purpose of the study was to evaluate the impact of high-dose versus standard-dose chemotherapy on the late neuropsychological outcome in randomized assigned high-risk breast cancer survivors. Next to focusing prevalence, function specificity and extent of cognitive impairment, the question as to whether doses-dependent group differences occur was investigated. PATIENTS AND METHODS: Twenty-four high-dose and 23 standard-dose patients 5 years, on average, after treatment underwent a comprehensive neuropsychological assessment. In addition, 29 early-stage breast cancer patients matched for age, education and time since treatment were recruited as a comparison group. RESULTS: Global cognitive impairment was observed in 8% of high-dose versus 13% of standard-dose compared with 3% of early-stage breast cancer patients. Compared with normative data, all patient groups performed worse on one attention subtest measuring the simple reaction time (P < 0.001 in each case). By contrast, no significant between-group differences on the late neuropsychological outcome were found. CONCLUSIONS: Five years after treatment, standard-dose patients were slightly, but not significantly, more impaired in cognitive performance than high-dose patients.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Trasplante de Células Madre / Pruebas Neuropsicológicas / Antineoplásicos Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2006 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Trasplante de Células Madre / Pruebas Neuropsicológicas / Antineoplásicos Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2006 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido