[Effect of growth hormone and parenteral nutrition on the catabolic phase following major digestive surgery]. / Efecto de la hormona del crecimiento y la nutrición parenteral sobre la fase catabólica tras cirugía digestiva mayor.
Rev Esp Enferm Dig
; 81(6): 379-82, 1992 Jun.
Article
en Es
| MEDLINE
| ID: mdl-1633010
The purpose of the present study was to determine if the administration of a biosynthetic human growth hormone (bGH) was able to enhance the efficacy of total parenteral nutrition (PN). Patients (n = 38) who had undergone major gastrointestinal surgery were randomly divided in two groups. Group I (n = 20) treated only with PN and Group II (n = 18) treated as in Group I plus bGH (4 UI/daily). Our study shows that the administration of bGH produces a significant increase in serum levels of growth hormone and Somatomedin-C. It also caused a positive nitrogen balance from the first 24 hours on (p less than 0.01). In Group II on day 12 after operation a statistically significant increase in transferrin (p less than 0.05), albumin (p less than 0.01) and total proteins (p less than 0.02) was observed. Our study suggest that the administration of bGH produces, perhaps through Somatomedin-C as mediator, an increase in protein synthesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cuidados Posoperatorios
/
Hormona del Crecimiento
/
Nutrición Parenteral Total
/
Enfermedades Gastrointestinales
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Rev Esp Enferm Dig
Asunto de la revista:
GASTROENTEROLOGIA
Año:
1992
Tipo del documento:
Article
País de afiliación:
Grenada
Pais de publicación:
España