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Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.
Lee, Kee-In; Park, Youmie; Park, Su-Jin; Hwang, Jung-Hwan; Lee, Sung-Jin; Kim, Gun-Do; Park, Woo-Kyu; Lee, Sunghou; Jeong, Daeyoung; Kong, Jae-Yang; Kang, Hee-Kyoung; Cho, Heeyeong.
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  • Lee KI; Division of Bio-Organic Science, Korea Research Institute of Chemical Technology, Daejeon 305-353, Republic of Korea.
Bioorg Med Chem Lett ; 16(3): 737-42, 2006 Feb.
Article en En | MEDLINE | ID: mdl-16321529
A series of dinaphtho[1,2-b;2',3'-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds with dialkylaminoethoxy group at C(5)-position (7, 8, 10, and 11) manifested strong inhibitory activities against epidermal growth factor receptor and vascular endothelial growth factor receptor. Docking study of 11 with EGFR was also performed.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinazolinas / Naftoquinonas / Proteínas Tirosina Quinasas Receptoras / Inhibidores Enzimáticos / Furanos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2006 Tipo del documento: Article Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinazolinas / Naftoquinonas / Proteínas Tirosina Quinasas Receptoras / Inhibidores Enzimáticos / Furanos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2006 Tipo del documento: Article Pais de publicación: Reino Unido