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Shedding of Mycobacterium bovis in the nasal mucus of cattle infected experimentally with tuberculosis by the intranasal and intratracheal routes.
McCorry, T; Whelan, A O; Welsh, M D; McNair, J; Walton, E; Bryson, D G; Hewinson, R G; Vordermeier, H M; Pollock, J M.
Afiliación
  • McCorry T; Department of Veterinary Science, Queen's University of Belfast, Stoney Road, Stormont.
Vet Rec ; 157(20): 613-8, 2005 Nov 12.
Article en En | MEDLINE | ID: mdl-16284329
Four groups of six calves were infected experimentally with either a low dose of approximately 10(4) colony-forming units (cfu) or a high dose of approximately 10(6) cfu of Mycobacterium bovis. Each dose was delivered by the intranasal and intratracheal routes. More severe disease was observed in the groups inoculated with the high dose. Visible lesions were identified in 21 of the 24 animals, all of which also gave positive skin tests and interferon-gamma (IFN-gamma) responses. Nasal shedding was detected in 15 of the 24 animals and the frequency of shedding was influenced by both the route and the dose of infection; no shedding was observed in the group infected intratracheally with the low dose. Two of the 15 confirmed shedders had no visible lesions at postmortem examination; both of these calves gave IFN-gamma responses but only one was skin test positive.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis Bovina / Mycobacterium bovis Límite: Animals Idioma: En Revista: Vet Rec Año: 2005 Tipo del documento: Article Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis Bovina / Mycobacterium bovis Límite: Animals Idioma: En Revista: Vet Rec Año: 2005 Tipo del documento: Article Pais de publicación: Reino Unido