Improved treatment results for childhood acute myeloid leukemia in Taiwan.

Liang, D C; Chan, T T; Lin, K H; Lin, D T; Lu, M Y; Chen, S H; Liu, H C; Lin, M T; Lee, M T; Shu, S G; Chang, T K; Chen, J S; Hsiao, C C; Hung, I J; Hsieh, Y L; Chen, R L; Cheng, S N; Chang, W H; Lee, C H; Lin, K S

Liang, D C; Chan, T T; Lin, K H; Lin, D T; Lu, M Y; Chen, S H; Liu, H C; Lin, M T; Lee, M T; Shu, S G; Chang, T K; Chen, J S; Hsiao, C C; Hung, I J; Hsieh, Y L; Chen, R L; Cheng, S N; Chang, W H; Lee, C H; Lin, K S.

Afiliación

Liang DC; Pediatric Hematology-Oncology Division, Mackay Memorial Hospital, Taipei, Taiwan.

Leukemia ; 20(1): 136-41, 2006 Jan.

Article en En | MEDLINE | ID: mdl-16281075

RESUMEN

To improve treatment results for children with de novo acute myeloid leukemia (AML), we introduced a novel protocol, Taiwan Pediatric Oncology Group-AML-97A, for AML other than acute promyelocytic leukemia (APL), for which modified conventional protocols were used. From January 1, 1997, to December 31, 2002, 141 children younger than 17 years old with de novo AML were enrolled. In total, 117 patients with non-APL AML were treated with induction therapy of idarubicin and cytarabine (Ara-C), postremission therapy with high-dose Ara-C - containing regimens for four monthly courses, and moderate-dose therapy with idarubicin and Ara-C for four monthly courses. The first 19 patients with APL were treated with all-trans retinoic acid, idarubicin and Ara-C, with the remaining five patients receiving all-trans retinoic acid and idarubicin, followed by maintenance therapy for 2 years. Stem cell transplantation was performed in 29 patients in first remission with a similar outcome as chemotherapy alone. The remission rate in the AML-97A study was 90%, the 5-year survival 51 +/- 5.3% (s.e.) and the 5-year event-free survival 50 +/- 4.8%; for APL, these were 100%, 86 +/- 7.0, and 75 +/- 9.8%. For the whole group, the 5-year survival was 57 +/- 4.7% and the 5-year event-free survival 54 +/- 4.4%. The AML-97A regimen was well tolerated.

Asunto(s)

Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico; Leucemia Mieloide Aguda/terapia; Leucemia Promielocítica Aguda/terapia; Trasplante de Células Madre; Adolescente; Niño; Preescolar; Supervivencia sin Enfermedad; Femenino; Estudios de Seguimiento; Humanos; Lactante; Recién Nacido; Masculino; Inducción de Remisión; Taiwán; Resultado del Tratamiento

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Leucemia Promielocítica Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Trasplante de Células Madre Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Asia Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2006 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido

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