Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine.
Eur J Neurosci
; 22(8): 2081-8, 2005 Oct.
Article
en En
| MEDLINE
| ID: mdl-16262645
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG trinucleotide repeat encoding an extended polyglutamine tract in the huntingtin protein. Affected individuals display progressive motor, cognitive and psychiatric symptoms (including depression), leading to terminal decline. Given that transgenic HD mice have decreased hippocampal cell proliferation and that a deficit in neurogenesis has been postulated as an underlying cause of depression, we hypothesized that decreased hippocampal neurogenesis contributes to depressive symptoms and cognitive decline in HD. Fluoxetine, a serotonin-reuptake inhibitor commonly prescribed for the treatment of depression, is known to increase neurogenesis in the dentate gyrus of wild-type mouse hippocampus. Here we show that hippocampal-dependent cognitive and depressive-like behavioural symptoms occur in HD mice, and that the administration of fluoxetine produces a marked improvement in these deficits. Furthermore, fluoxetine was found to rescue deficits of neurogenesis and volume loss in the dentate gyrus of HD mice.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fluoxetina
/
Inhibidores Selectivos de la Recaptación de Serotonina
/
Enfermedad de Huntington
/
Trastornos del Conocimiento
/
Proliferación Celular
/
Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Francia